Subramaniam Ganesh Selected Research

polyglucosan

12/2017	Suppression of leptin signaling reduces polyglucosan inclusions and seizure susceptibility in a mouse model for Lafora disease.
1/2016	FoxO3a-mediated autophagy is down-regulated in the laforin deficient mice, an animal model for Lafora progressive myoclonus epilepsy.
12/2015	Interdependence of laforin and malin proteins for their stability and functions could underlie the molecular basis of locus heterogeneity in Lafora disease.
8/2015	Lafora disease proteins laforin and malin negatively regulate the HIPK2-p53 cell death pathway.
10/2011	Increased glucose concentration results in reduced proteasomal activity and the formation of glycogen positive aggresomal structures.
2/2009	The malin-laforin complex suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system.
4/2007	Lafora disease proteins malin and laforin are recruited to aggresomes in response to proteasomal impairment.
1/2004	The carbohydrate-binding domain of Lafora disease protein targets Lafora polyglucosan bodies.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Subramaniam Ganesh Research Topics

Disease

23	Lafora Disease 03/2024 - 05/2002
19	Neurodegenerative Diseases (Neurodegenerative Disease) 03/2024 - 04/2007
5	Alzheimer Disease (Alzheimer's Disease) 01/2022 - 08/2009
5	Seizures (Absence Seizure) 03/2021 - 05/2002
5	Epilepsy (Aura) 09/2013 - 05/2002
3	Progressive Myoclonic Epilepsies (Progressive Myoclonic Epilepsy) 03/2024 - 03/2002
3	Huntington Disease (Huntington's Disease) 10/2023 - 01/2018
3	Neuroinflammatory Diseases 09/2022 - 01/2021
3	Myoclonic Epilepsies (Myoclonic Encephalopathy) 12/2013 - 05/2002
2	Insulin Resistance 01/2022 - 01/2019
2	Gliosis 03/2021 - 12/2017
2	Hypoxia (Hypoxemia) 11/2020 - 01/2020
2	Stroke (Strokes) 01/2008 - 01/2007
1	Memory Disorders (Memory Loss) 10/2022
1	Cognitive Dysfunction 01/2022
1	Starvation 12/2021
1	Parkinson Disease (Parkinson's Disease) 12/2021
1	Amyloidosis 01/2021
1	Inborn Genetic Diseases (Disease, Hereditary) 01/2019
1	Diabetes Mellitus 01/2019
1	Febrile Seizures (Febrile Seizure) 09/2013
1	Asthma (Bronchial Asthma) 08/2011
1	Coronary Artery Disease (Coronary Atherosclerosis) 01/2011
1	Tauopathies 08/2009
1	Ataxia (Dyssynergia) 05/2002

Drug/Important Bio-Agent (IBA)

14	Proteins (Proteins, Gene)FDA Link 09/2018 - 09/2003
12	GlycogenIBA 10/2023 - 10/2011
8	polyglucosanIBA 12/2017 - 01/2004
4	Insulin (Novolin)FDA Link 01/2022 - 12/2018
4	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2017 - 10/2008
3	CarbohydratesIBA 01/2012 - 01/2004
3	Dual-Specificity PhosphatasesIBA 05/2002 - 03/2002
2	Glycogen Synthase (Synthase I)IBA 10/2023 - 01/2018
2	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 01/2017 - 12/2012
1	Retinaldehyde (Retinal)IBA 03/2024
1	AmalakirasayanaIBA 10/2022
1	Streptozocin (Streptozotocin)FDA Link 01/2022
1	Small Interfering RNA (siRNA)IBA 01/2022
1	PesticidesIBA 12/2021
1	TrehaloseIBA 03/2021
1	Dexamethasone (Maxidex)FDA LinkGeneric 01/2021
1	Anticonvulsants (Antiepileptic Drugs)IBA 01/2021
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2020
1	polyglutamineIBA 01/2019
1	Huntingtin ProteinIBA 01/2018
1	LeptinIBA 12/2017
1	Leptin ReceptorsIBA 12/2017
1	Heat Shock Transcription FactorsIBA 01/2017
1	Ligases (Synthetase)IBA 01/2016
1	UbiquitinIBA 01/2016
1	Phosphotransferases (Kinase)IBA 12/2013
1	GlucocorticoidsIBA 12/2013
1	Sodium Channels (Sodium Channel)IBA 09/2013
1	Messenger RNA (mRNA)IBA 12/2012
1	MicroRNAs (MicroRNA)IBA 12/2012
1	mRNA decapping enzymesIBA 12/2012
1	Protein Isoforms (Isoforms)IBA 01/2012
1	Mutant Proteins (Protein, Mutant)IBA 08/2011
1	DisintegrinsIBA 08/2011
1	Metalloproteases (Metalloproteinases)IBA 08/2011
1	Aryldialkylphosphatase (Paraoxonase)IBA 01/2011
1	Methylenetetrahydrofolate Reductase (NADPH2) (Methylenetetrahydrofolate Reductase)IBA 01/2011
1	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA 01/2011
1	Phosphoprotein Phosphatases (Phosphatases, Protein)IBA 08/2009
1	tau Proteins (tau Protein)IBA 08/2009
1	Interleukin-6 (Interleukin 6)IBA 01/2008
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2008
1	Apolipoproteins E (ApoE)IBA 01/2007
1	Genetic Markers (Genetic Marker)IBA 01/2003
1	Periodic AcidIBA 05/2002
1	Prednisolone (Predate)FDA LinkGeneric 05/2002

Therapy/Procedure

1	Injections 01/2021